Kbi-058 Link -

DYRK1A is a proline-directed kinase encoded on human chromosome 21. Its overexpression is implicated in early-onset neurodegeneration and cognitive dysfunction. Current therapeutic options remain symptomatic; thus, selective DYRK1A inhibitors are highly sought after. Through a structure-based virtual screen of a 500,000-compound library, followed by hit-to-lead optimization, we identified (IUPAC: N-(3-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl)-2,4-difluorobenzenesulfonamide ). This paper describes its preclinical profile.

Stop scheduling back-to-back meetings. Block out 30 to 60 minutes a day of literal "nothing" on your calendar. Treat this block with the same respect you would a meeting with your boss. Use this time to think, breathe, or just stare out the window. KBI-058